Evidence supporting the use of: Butyrate triglyceride
For the health condition: Leaky Gut Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Butyrate triglyceride, a form of butyrate (a short-chain fatty acid), has garnered scientific interest for its potential role in supporting gut health, including conditions like Leaky Gut Syndrome (increased intestinal permeability). Butyrate is naturally produced in the colon by fermentation of dietary fibers and serves as a primary energy source for colonocytes (colon lining cells). Studies—mainly in animals and in vitro—show that butyrate can enhance the integrity of the intestinal barrier by upregulating tight junction proteins and reducing inflammation. This suggests it may help counteract the mechanisms underlying increased gut permeability. Butyrate triglyceride is a supplemental form designed to deliver butyrate efficiently to the lower gut. Early research indicates that oral butyrate or butyrate triglyceride can ameliorate gut barrier dysfunction in animal models and some small human studies, mainly in the context of inflammatory bowel diseases. However, direct evidence for its efficacy in treating Leaky Gut Syndrome in humans remains limited. Most human data is extrapolated from related gastrointestinal disorders, and large, well-controlled clinical trials are lacking. In summary, while there is a plausible biological mechanism and some preliminary supportive data, the evidence is not yet robust, and its use for Leaky Gut Syndrome is not firmly established. The scientific rationale exists, but clinical validation is still emerging.

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