Evidence supporting the use of: Fructo-Oligosaccharides (FOS)
For the health condition: Leaky Gut Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fructo-Oligosaccharides (FOS) are prebiotic fibers that have been investigated for their potential to support gut health, including conditions like "Leaky Gut Syndrome" (increased intestinal permeability). Scientific research shows that FOS can stimulate the growth of beneficial gut bacteria, particularly Bifidobacteria and Lactobacilli. These bacteria can enhance the production of short-chain fatty acids (SCFAs) such as butyrate, which have been shown in animal and in vitro studies to help maintain the integrity of the intestinal barrier by supporting tight junction proteins and reducing inflammation.

However, direct evidence supporting the use of FOS specifically for "Leaky Gut Syndrome" in humans is limited. Most studies focus on the general improvement of gut microbiota and barrier function rather than on clinical outcomes related to leaky gut in humans. Some small studies and animal models suggest that FOS supplementation can reduce intestinal permeability and systemic inflammation, but robust, large-scale clinical trials in humans are lacking.

Overall, the scientific rationale for using FOS centers on its prebiotic effect and its influence on gut barrier function via modulation of the microbiome and SCFA production. While this provides a plausible mechanism, the evidence supporting FOS as a treatment for "Leaky Gut Syndrome" in humans remains preliminary, warranting a modest evidence rating.

More about Fructo-Oligosaccharides (FOS)
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Products containing Fructo-Oligosaccharides (FOS)

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