Galactooligosaccharides (GOS) are prebiotic fibers known to promote the growth of beneficial gut bacteria such as Bifidobacteria and Lactobacilli. Their use in supporting or treating "Leaky Gut Syndrome"—also known as increased intestinal permeability—is based on emerging scientific research, though the evidence is still preliminary and primarily from animal studies or small human trials.

Several animal studies have demonstrated that GOS supplementation can improve gut barrier function, reduce intestinal inflammation, and enhance the expression of tight junction proteins, which are crucial for maintaining intestinal integrity. For example, research in rodent models has shown that GOS can help restore tight junctions and reduce markers of gut permeability induced by stress or high-fat diets.

Human data are more limited. Some small clinical trials in humans suggest that GOS can positively modulate the gut microbiota and may reduce inflammation, potentially benefiting intestinal barrier function. However, there is not yet robust clinical evidence directly linking GOS supplementation to significant improvements in "Leaky Gut Syndrome" in humans. The concept of "Leaky Gut Syndrome" itself remains controversial, with no universally accepted diagnostic criteria.

In summary, the use of GOS for supporting gut barrier function is scientifically plausible and supported by early evidence, but current clinical validation is limited. More high-quality human studies are needed to confirm its efficacy for this specific condition.