Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glutamine is an amino acid that has gained popularity as a supplement for supporting intestinal health, particularly in the context of "Leaky Gut Syndrome" (increased intestinal permeability). There is some scientific rationale and preliminary research supporting its use, though the evidence is not robust or definitive, especially in the context of human clinical trials for Leaky Gut Syndrome specifically.

Animal and in vitro studies have shown that glutamine is a major fuel source for enterocytes (the cells lining the intestines) and helps maintain the integrity of the gut barrier by supporting tight junction proteins. Some small human studies have found that glutamine supplementation may reduce intestinal permeability in critically ill patients or those undergoing certain medical treatments (e.g., chemotherapy), but these patient populations are not fully representative of the general population seeking to address "leaky gut."

There is a lack of large, well-controlled clinical trials directly demonstrating that L-glutamine supplementation can treat or reverse Leaky Gut Syndrome in otherwise healthy individuals or those with vague gastrointestinal complaints. As such, while there is scientific plausibility and some encouraging preliminary data, the strength of evidence remains limited (rated 2/5). More research is needed to establish clear clinical guidelines for L-glutamine use in this context.

More about l-glutamine
More about Leaky Gut Syndrome

Other ingredients used for Leaky Gut Syndrome

Other health conditions supported by l-glutamine

Products containing l-glutamine

Douglas Laboratories 5-HTP Plus Formula
Designs For Health Amino-D-Tox™
Designs For Health Amino-D-Tox™
Pure Encapsulations Amino-NR
Pure Encapsulations Amino Replete
Designs For Health BCAA Powder with L-Glutamine
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus pH
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Vanilla
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Berry
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Chai
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Vanilla
Integrative Therapeutics Detoxication Factors
Integrative Therapeutics Detoxication Factors
Thorne EnteroMend NSF
Pure Encapsulations EpiIntegrity
Pure Encapsulations G.I. Fortify
Pure Encapsulations G.I. Fortify
Pure Encapsulations G.I. Integrity
Pure Encapsulations G.I. Integrity
Designs For Health GI Revive®
Designs For Health GI Revive®
Metagenics GI Sustain™ Powder
Metagenics Glutagenics® powder
Integrative Therapeutics Glutamine Forte Drink Mix
Vitabase HGH Complex
Designs For Health IBSynergy™
Klean Athlete Klean Essential Aminos + HMB®
Klean Athlete Klean Isolate ™
Thorne L-Glutamine
Pure Encapsulations l-Glutamine
Designs For Health L-Glutamine
Douglas Laboratories L-Glutamine
Pure Encapsulations l-Glutamine 500 mg
Pure Encapsulations l-Glutamine 850 mg
Pure Encapsulations l-Glutamine 850 mg
Designs For Health L-Glutamine Powder
Designs For Health L-Glutamine Powder
Douglas Laboratories L-Glutamine Powder
Thorne L-Glutamine Powder NSF
Pure Encapsulations Liver G.I. Detox
Thorne MediClear Plus
Integrative Therapeutics Multiplex-1 No-Iron
Douglas Laboratories Muscle Protect™ with HMB®
Designs For Health Neurolink™
Integrative Therapeutics Nutrivitamin No-Iron
Pure Encapsulations PureBi•Ome™ G.I.
Metagenics Ultra Potent-C 1000
Metagenics Ultra Potent-C Chewable
Metagenics UltraClear Plus® Detox Powder
Metagenics UltraClear Plus Detox Powder Berry
Metagenics UltraClear Plus Detox Powder Pineapple/Banana
Metagenics UltraClear Plus pH Detox Powder Pineapple/Banana
Metagenics UltraClear Plus pH Detox Powder Vanilla
Metagenics UltraClear RENEW Detox Powder Berry
Metagenics UltraClear RENEW Detox Powder Chai
Metagenics UltraClear RENEW Detox Powder Vanilla
Pure Encapsulations UltraDetox 10-Day Pure Pack
Metagenics UltraGI Replenish® Chocolate
Metagenics UltraGI Replenish Chocolate
Metagenics UltraGI Replenish Vanilla
Metagenics UltraGI Replenish Vanilla
Metagenics UltraInflamX Plus 360°® Chocolate/Orange
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Orange
Metagenics UltraInflamX Plus 360° Original Spice
Metagenics UltraInflamX Plus 360° Pineapple/Banana
Metagenics UltraInflamX Plus 360° Pineapple/Banana