Evidence supporting the use of: Lactobacillus
For the health condition: Leaky Gut Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus, a genus of probiotic bacteria, is commonly used in supplements and some clinical interventions aimed at supporting gut health, including conditions described as "Leaky Gut Syndrome" (increased intestinal permeability). The use of Lactobacillus for this condition is supported by a modest but growing body of scientific evidence, though much of it stems from preclinical studies or small human trials rather than large-scale, definitive clinical trials.

Several in vitro and animal studies have demonstrated that certain strains of Lactobacillus can enhance the integrity of the intestinal barrier by modulating tight junction proteins and reducing inflammation. For example, Lactobacillus rhamnosus GG has been shown to upregulate the expression of tight junction proteins such as occludin and zonula occludens-1 (ZO-1) in cell culture and animal models. Some small human trials have reported improvements in intestinal permeability markers in specific patient populations (such as those with irritable bowel syndrome or after non-steroidal anti-inflammatory drug use) following supplementation with Lactobacillus strains.

However, the overall quality of evidence is limited. The concept of "Leaky Gut Syndrome" itself is not universally recognized as a formal medical diagnosis, and most studies address related conditions or endpoints (e.g., intestinal permeability, inflammation) rather than the syndrome per se. As such, while there is scientific rationale and some supporting data, the evidence base is not robust enough to warrant a high confidence rating.

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Products containing Lactobacillus

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