Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus brevis is a probiotic bacterium that has been investigated for its potential benefits in gut health, including the management of Leaky Gut Syndrome (also known as increased intestinal permeability). The scientific rationale for using L. brevis centers on its ability to modulate the gut microbiota, enhance mucosal barrier integrity, and reduce inflammation. Several in vitro and animal studies have demonstrated that L. brevis can increase the expression of tight junction proteins (such as occludin and claudin), which are crucial for maintaining the intestinal barrier. For example, a 2016 study published in "Frontiers in Microbiology" showed that L. brevis improved gut barrier function and reduced the permeability caused by pathogenic bacteria in mouse models.

However, direct clinical evidence in humans with Leaky Gut Syndrome is limited. Most of the evidence comes from laboratory and animal research, with only a handful of small human studies evaluating the effect of L. brevis on general gut health or inflammation. While these findings are promising and suggest a possible role for L. brevis in supporting intestinal barrier function, they do not yet provide conclusive evidence for its use as a treatment for Leaky Gut Syndrome in humans. Thus, the current evidence rating is 2/5—there is some preliminary scientific support, but more robust human clinical trials are needed to validate its effectiveness for this specific condition.

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Products containing lactobacillus brevis

Douglas Laboratories Multi-Probiotic ® 40 Billion
Douglas Laboratories Multi-Probiotic ® 40 Billion