Evidence supporting the use of: Lactobacillus casei
For the health condition: Leaky Gut Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus casei is a probiotic bacterium that has been investigated for its potential role in supporting gut health, including conditions like Leaky Gut Syndrome (also known as increased intestinal permeability). The scientific rationale for using L. casei is based primarily on its ability to modulate the gut microbiota, enhance the mucosal barrier, and regulate immune responses. Animal and in vitro studies suggest that L. casei supplementation can upregulate tight junction proteins (such as occludin and claudin), which are critical for maintaining the integrity of the intestinal barrier. Additionally, it has been shown to reduce inflammatory cytokines and decrease gut permeability in various experimental models.

However, while these mechanisms are promising, direct clinical evidence in humans specifically for Leaky Gut Syndrome is limited. Most human studies with L. casei focus on related conditions, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and general digestive health. Some of these studies show improved gut barrier function and reduced symptoms, but few directly measure markers of intestinal permeability in the context of "Leaky Gut Syndrome" as it is popularly understood.

In summary, there is a scientific basis and some supporting evidence for the use of L. casei in improving gut barrier integrity, but robust clinical trials specifically for Leaky Gut Syndrome are lacking. Therefore, while its use is not purely traditional and there is some scientific support, the strength of evidence remains moderate to low.

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