Evidence supporting the use of: Lactobacillus gasseri
For the health condition: Leaky Gut Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus gasseri is a probiotic bacterium naturally present in the human gut and is commonly found in some fermented foods. Its use for supporting or treating Leaky Gut Syndrome (increased intestinal permeability) is based primarily on scientific exploration rather than traditional medicine. Some in vitro and animal studies suggest that L. gasseri may help reinforce intestinal barrier function by enhancing tight junction integrity and modulating inflammation. For example, research in rodent models has shown that supplementation with L. gasseri can reduce gut permeability and improve gut barrier protein expression, possibly due to its anti-inflammatory effects and ability to balance gut microbiota composition. Additionally, some small clinical trials in humans have investigated its impact on gut health, with limited but promising results regarding improved intestinal symptoms and reduced markers of inflammation.

However, direct high-quality clinical evidence in humans specifically targeting Leaky Gut Syndrome is limited. Most available studies are small, short in duration, or use L. gasseri as part of a probiotic mix, making it difficult to isolate its individual effects. As a result, while there is a scientific rationale and some preliminary evidence for using Lactobacillus gasseri to support gut barrier function, more robust clinical trials are needed to confirm its efficacy for Leaky Gut Syndrome. The current level of evidence can be considered modest but promising, justifying a rating of 2 out of 5.

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