Evidence supporting the use of: Lactobacillus johnsonii
For the health condition: Leaky Gut Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus johnsonii is a probiotic bacterium that has been investigated for its role in supporting gut health, including “Leaky Gut Syndrome” (increased intestinal permeability). There is some preclinical scientific evidence to support its use, though high-quality human trials are lacking. Animal studies have shown that L. johnsonii can help maintain and restore the integrity of the intestinal epithelial barrier. For example, research in mice has demonstrated that supplementation with L. johnsonii reduces intestinal permeability, modulates the immune response, and enhances the production of tight junction proteins, which are crucial for maintaining the gut barrier.[1][2]

In vitro studies have also indicated that this probiotic can inhibit the growth of pathogenic bacteria and reduce inflammation, both of which are factors that contribute to “leaky gut.” However, evidence in humans is very limited. Most clinical studies examining probiotics for leaky gut use multi-strain formulations, making it difficult to isolate the effects of L. johnsonii alone.

In summary, while there is some scientific rationale and promising animal data supporting the use of Lactobacillus johnsonii to help with increased intestinal permeability, the current level of evidence in humans is preliminary and does not yet robustly justify its use for “Leaky Gut Syndrome.” More well-designed clinical trials are needed.

[1] Yan F, Polk DB. Probiotics and immune health. Curr Opin Gastroenterol. 2011;27(6):496-501.
[2] Miyauchi E, et al. Mechanisms underlying the anti-inflammatory and barrier function effects of Lactobacillus johnsonii. Front Microbiol. 2017;8:1501.

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