Evidence supporting the use of: Lactobacillus salivarius
For the health condition: Leaky Gut Syndrome

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus salivarius is a probiotic bacterium commonly found in the human gastrointestinal tract and oral cavity. Its use to support or treat "Leaky Gut Syndrome" (also known as increased intestinal permeability) is grounded primarily in scientific investigation rather than tradition or long-standing folk use. Several in vitro and animal studies have shown that L. salivarius can help maintain the integrity of the gut barrier, reduce inflammation, and support a healthy balance of intestinal microbiota. For example, research in animal models has demonstrated that certain strains of L. salivarius can increase expression of tight junction proteins, reduce markers of inflammation, and lessen gut permeability under stress or pathological conditions. Small-scale human studies have also suggested potential benefits in reducing gastrointestinal symptoms and inflammation, but these studies are limited in size and scope.

However, direct high-quality clinical trials evaluating L. salivarius specifically for "Leaky Gut Syndrome" in humans are lacking. Most evidence is extrapolated from broader studies on gut health, irritable bowel syndrome, or general probiotic effects. As a result, while there is some scientific rationale and preliminary data supporting its use, the overall quality and quantity of evidence is still limited, meriting a modest rating of 2 out of 5. Further large-scale, controlled clinical trials are needed to firmly establish its efficacy for this condition.

More about lactobacillus salivarius
More about Leaky Gut Syndrome