Evidence supporting the use of: Probiotic (unspecified)
For the health condition: Leaky Gut Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. Their use for "leaky gut syndrome"—more formally known as increased intestinal permeability—has gained attention in recent years, and there is some scientific rationale and preliminary evidence supporting their potential benefit. Several studies suggest that specific strains of probiotics can help maintain or restore the integrity of the intestinal barrier by modulating tight junction proteins, reducing inflammation, and promoting a healthy gut microbiota. However, the clinical concept of "leaky gut syndrome" as a discrete, diagnosable condition is not universally accepted in mainstream medicine, and most research focuses on increased intestinal permeability in the context of specific diseases (such as inflammatory bowel disease, irritable bowel syndrome, or critical illness) rather than as an isolated syndrome. While some human and animal studies have shown that certain probiotic strains (such as Lactobacillus rhamnosus GG, Bifidobacterium species, and others) may reduce intestinal permeability and associated symptoms, the evidence is inconsistent, strain-specific, and often based on small sample sizes or surrogate endpoints. There are no large, high-quality clinical trials conclusively demonstrating that probiotics are effective for the treatment of "leaky gut syndrome" as popularly defined. Therefore, while there is a scientific basis for their potential use, the overall quality of evidence is low to moderate, and further research is needed.

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