Evidence supporting the use of: Xylooligosaccharides
For the health condition: Leaky Gut Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Synopsis: Xylooligosaccharides (XOS) are prebiotic fibers derived from plant-based sources such as corn cobs and bamboo. They are not traditionally used in herbal or folk medicine for gut health or “leaky gut syndrome,” but their inclusion in functional foods and supplements is based on emerging scientific evidence. XOS selectively stimulates the growth of beneficial gut bacteria, particularly Bifidobacterium and Lactobacillus species, which are associated with improved intestinal barrier function. Animal studies and limited human clinical trials suggest that XOS supplementation can enhance the production of short-chain fatty acids (SCFAs) like butyrate, which play a role in strengthening tight junctions and reducing gut permeability—key factors in the pathogenesis of “leaky gut.”

However, evidence directly linking XOS to the treatment or prevention of “leaky gut syndrome” in humans is currently limited. Most studies focus on general improvements in gut microbiota composition and inflammatory markers, rather than clinically validated outcomes for increased intestinal permeability or symptom improvement in leaky gut. While the theoretical basis is strong, and preclinical findings are promising, more rigorous, large-scale human trials are needed to confirm efficacy for this specific condition.

In summary, XOS has a scientifically plausible mechanism and emerging preliminary evidence for supporting gut barrier function, meriting a modest evidence rating of 2/5 for the treatment of leaky gut syndrome at this time.

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