Evidence supporting the use of: Streptomyces (unspecified)
For the health condition: Leprosy

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Streptomyces species, particularly Streptomyces griseus, are the original source of the antibiotic streptomycin. Streptomycin was discovered in the 1940s and became the first effective antibiotic treatment for tuberculosis and, to a lesser extent, leprosy (Hansen’s disease). Leprosy is caused by Mycobacterium leprae, a bacterium that is closely related to Mycobacterium tuberculosis. Before the advent of multidrug therapy, streptomycin was sometimes used, either alone or in combination with other agents such as dapsone and clofazimine, to treat leprosy cases, especially those resistant to sulfone drugs.

However, streptomycin is not the current drug of choice for leprosy. The standard regimen now recommended by the World Health Organization (WHO) includes dapsone, rifampicin, and clofazimine, not streptomycin. The use of streptomycin against M. leprae is supported by early clinical studies showing partial effectiveness, but it is less effective than the current first-line treatments. Historically, the justification for its use is strictly scientific, based on its antibiotic properties and demonstrated (though limited) activity against M. leprae.

In summary, Streptomyces (as the source of streptomycin) was once used in the clinical management of leprosy based on scientific evidence, but it has been largely replaced by more effective therapies.

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