Evidence supporting the use of: Allantoin
For the health condition: Lesions

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Allantoin is a compound commonly found in skincare products and topical medications, particularly for the management of minor skin injuries, irritation, and lesions. Its use is primarily justified by scientific evidence, albeit modest in strength. Allantoin has well-documented keratolytic (promoting the shedding of dead skin cells), moisturizing, and soothing properties, contributing to its frequent inclusion in formulations for wound healing and lesion management. Studies indicate that allantoin can promote cell proliferation and encourage the repair of damaged epithelial tissue, which can be beneficial for superficial lesions such as abrasions, minor cuts, and ulcers.

However, the clinical evidence supporting allantoin’s efficacy is mostly limited to in vitro (cell culture) and animal studies, as well as small-scale human studies. These studies report improved wound healing rates and reduction in irritation, but high-quality, large-scale randomized controlled trials in humans are lacking. Regulatory bodies such as the US FDA have recognized allantoin as a skin protectant for over-the-counter use in minor wounds, burns, and skin irritations, which reflects a consensus of safety and some efficacy. Overall, while allantoin is widely used and has some scientific rationale for supporting lesion healing, the strength of evidence is moderate and further research is warranted to fully substantiate its benefits for this indication.

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Products containing Allantoin

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