Dragon's Blood refers to the red resin obtained from various plant species, most notably Croton lechleri. Its use for treating skin lesions has both traditional and scientific backing. Traditionally, indigenous populations in South America have applied Dragon's Blood topically to wounds, cuts, and ulcers to accelerate healing and prevent infection. This ethnomedicinal application prompted scientific exploration into its efficacy and mechanisms of action.

Scientific studies have supported some of these traditional uses. Research has demonstrated that Dragon's Blood contains bioactive compounds such as proanthocyanidins, taspine, and phenolic compounds, which exhibit antimicrobial, anti-inflammatory, and wound-healing properties. Several in vitro and animal studies report that extracts from Croton lechleri can promote fibroblast migration, collagen deposition, and re-epithelialization—key processes in lesion repair. A few small clinical studies and case reports have suggested beneficial effects in human wound and ulcer healing, though robust randomized controlled trials are limited.

Overall, while Dragon's Blood has a strong traditional foundation for use in lesions, and preliminary scientific evidence supports its wound-healing and antimicrobial activities, more high-quality human research is needed to fully validate its efficacy and safety for this indication.