Henna (Lawsonia inermis) has a long history of use in traditional medicine, particularly in South Asia, the Middle East, and North Africa. Traditionally, henna paste is applied topically to skin lesions, wounds, burns, and ulcers. This practice is rooted in folk medicine, where it is believed to have cooling, antimicrobial, and healing properties. The reddish dye (lawsone) in henna is thought to create a protective barrier over lesions, potentially helping to prevent infection and promote healing.

Some in vitro and animal studies have demonstrated antimicrobial and anti-inflammatory properties of henna extracts, which could theoretically support its use for superficial skin lesions. For instance, certain studies report that henna extracts exhibit antibacterial activity against common skin pathogens. However, these findings have not translated into substantial clinical evidence from human trials. There is a lack of rigorous, controlled studies in humans demonstrating efficacy or safety for lesion healing.

Therefore, while henna's use for treating lesions is well-established in traditional medicine, current scientific evidence is limited and largely preclinical. Its use should be approached with caution, as allergic reactions and contact dermatitis can occur in some individuals. Overall, henna's application for lesions is justified by traditional practices rather than robust scientific validation.