Lanolin, a natural, waxy substance derived from the wool of sheep, has been widely used in dermatology and wound care. Its primary use in supporting or treating lesions is based on its emollient and occlusive properties. Lanolin creates a protective barrier over the skin, which helps retain moisture, thereby supporting the healing of dry, cracked, or superficial skin lesions. This mechanism is supported by several clinical and laboratory studies indicating that lanolin can accelerate re-epithelialization and reduce transepidermal water loss in damaged skin.

For example, studies have shown that purified lanolin can improve the healing of nipple fissures in breastfeeding women and minor skin abrasions. Lanolin’s ability to support the skin barrier function makes it useful in managing superficial wounds and minor lesions by preventing desiccation and secondary infection. However, while there is moderate scientific validation for lanolin's use in treating minor lesions, evidence is less robust for its effectiveness in managing deeper or infected wounds, and some people may experience allergic reactions.

Overall, lanolin’s use for superficial lesions is primarily justified by both empirical evidence and clinical research, particularly in areas such as dermatology and wound care. It is not recommended for all lesion types, but its efficacy in promoting the healing of minor skin lesions is moderately supported by scientific literature.