Panthenol, also known as provitamin B5, is frequently incorporated into topical formulations for wound healing and the treatment of minor skin lesions. Several studies and clinical trials provide scientific support for its efficacy in this context. Panthenol is rapidly absorbed by the skin and converted into pantothenic acid, a key component of coenzyme A, which is vital for cellular repair and regeneration. Research suggests that topical application of panthenol can enhance skin hydration, improve the barrier function, and accelerate re-epithelialization, all of which are beneficial for healing skin lesions, abrasions, and minor wounds.

For example, a randomized controlled trial published in "Cutaneous and Ocular Toxicology" (2014) showed that panthenol-containing creams significantly improved wound healing rates and reduced inflammation compared to placebo. Additional in vitro and animal studies support these findings, demonstrating enhanced fibroblast proliferation and faster closure of excised wounds. Panthenol also exhibits anti-inflammatory properties, which can help reduce redness and discomfort associated with lesions.

While evidence is promising and panthenol is widely used in clinical dermatology, most studies focus on minor, uncomplicated lesions rather than severe or chronic wounds. The overall quality of evidence is moderate (rated 3/5), reflecting consistent positive findings but a need for larger, high-quality randomized controlled trials to further clarify its role and optimal usage parameters.