Evidence supporting the use of: Sangre de Grado
For the health condition: Lesions

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Sangre de Grado (also known as Dragon’s Blood, derived from the sap of the Croton lechleri tree) has a long history of traditional use in South American medicine for the treatment of skin lesions, cuts, and wounds. In addition to this traditional use, there is a growing body of scientific evidence supporting its efficacy in treating lesions. Multiple studies have demonstrated that Sangre de Grado contains bioactive compounds, such as proanthocyanidins (notably taspine), which possess anti-inflammatory, antimicrobial, and wound-healing properties. In vitro and in vivo studies have shown that topical application of the sap can accelerate wound contraction, promote re-epithelialization, and reduce microbial contamination in lesions. A randomized, double-blind clinical trial published in the journal Phytomedicine (2011) found that Sangre de Grado cream significantly improved the healing of skin wounds compared to placebo. Additionally, its hemostatic effect—rapidly forming a protective barrier over wounds—has been documented in both traditional and clinical settings. Although more large-scale, high-quality clinical trials would further strengthen the evidence, current research supports its use for lesion care, earning it a relatively high evidence rating.

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