Evidence supporting the use of: RNA
For the health condition: Leukemia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ribonucleic acid (RNA) and related nucleotides have been investigated as supportive treatments in various cancers, including leukemia, primarily as a component of immunomodulatory or nutritional therapies. Some clinical studies and experimental evidence suggest that dietary nucleotides or RNA extracts might help support hematopoiesis (blood cell formation) and immune function, especially in patients undergoing chemotherapy, which can suppress the bone marrow. For example, certain early studies have explored yeast RNA or nucleic acid supplementation to aid recovery of white blood cells and improve immune response after intensive cancer treatment. However, these studies are generally small, dated, and sometimes methodologically limited. Meta-analyses or large randomized controlled trials directly supporting RNA supplementation as a primary or adjunctive therapy in leukemia are lacking. In contemporary clinical practice, RNA as a direct supplement is not a standard treatment for leukemia. Instead, modern "RNA-based therapies" (such as antisense oligonucleotides or mRNA vaccines) are being explored in oncology, but these are highly targeted molecular agents rather than dietary RNA. Thus, the evidence supporting the use of RNA extracts or dietary RNA for leukemia is limited and not robustly validated. Most guidelines do not recommend RNA supplementation for leukemia outside of experimental protocols. In summary, while there is some scientific rationale and preliminary evidence, the overall support is weak (evidence rating: 2/5) and not sufficient to justify routine clinical use.

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