Evidence supporting the use of: Stem Cells
For the health condition: Leukemia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Stem cell transplantation, particularly hematopoietic stem cell transplantation (HSCT), is a scientifically validated and widely accepted treatment for leukemia. Leukemia is a cancer of the blood-forming tissues, such as the bone marrow, resulting in the production of abnormal white blood cells. High-dose chemotherapy and sometimes radiation therapy are used to destroy the malignant cells, but these treatments also damage the patient’s normal bone marrow. HSCT involves the infusion of hematopoietic stem cells—either from the patient (autologous) or from a donor (allogeneic)—to restore the bone marrow’s ability to produce healthy blood cells after intensive therapy. Numerous clinical trials and decades of clinical practice have established the efficacy of stem cell transplantation in various types of leukemia, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and certain cases of chronic leukemias. Allogeneic HSCT, in particular, offers the benefit of a “graft-versus-leukemia” effect, whereby donor immune cells help eliminate residual malignant cells. Survival rates and cure rates for certain high-risk or relapsed leukemias are significantly improved with HSCT compared to chemotherapy alone. Major medical organizations, such as the American Society of Hematology and the National Comprehensive Cancer Network, include stem cell transplantation in their guidelines for leukemia treatment. Thus, the use of stem cells in the management of leukemia is supported by robust scientific evidence, with ongoing research aimed at optimizing outcomes and reducing complications.

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