Evidence supporting the use of: Vitamin B9 (folinic acid)
For the health condition: Leukemia

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Folinic acid (also known as leucovorin) is scientifically validated for use in supporting or treating leukemia, but not as a direct anti-leukemic agent. Its primary role is as a "rescue" therapy in patients receiving high-dose methotrexate, a chemotherapy drug commonly used to treat certain types of leukemia (such as acute lymphoblastic leukemia). Methotrexate inhibits dihydrofolate reductase, leading to depletion of tetrahydrofolate and interfering with DNA synthesis, which is toxic to rapidly dividing cancer cells but can also harm normal cells. Folinic acid is a reduced form of folate that bypasses this block, selectively rescuing normal cells from the toxic effects of methotrexate without diminishing the drug's anti-cancer efficacy against malignant cells. This use is well established in oncology and is supported by decades of clinical trials and treatment guidelines.

Folinic acid may also be used to manage or prevent adverse effects from other antifolate drugs used in leukemia treatment. However, it is not used as a primary or standalone treatment for leukemia itself, nor does it have direct anti-leukemic properties. Its use is supported by strong evidence and is part of standard treatment protocols in pediatric and adult oncology.

More about Vitamin B9 (folinic acid)
More about Leukemia

Products containing Vitamin B9 (folinic acid)

We currently have no products on Vitabase that contain this ingredient.