Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Insulin-like growth factor (IGF-1) has been investigated in scientific studies for its potential to support the repair and healing of ligaments, particularly after injury. IGF-1 is a peptide hormone with anabolic effects, promoting cell proliferation and protein synthesis. Preclinical studies in animal models have demonstrated that local application or increased expression of IGF-1 can enhance the healing of ligaments by stimulating fibroblast proliferation, collagen synthesis, and matrix remodeling. For example, research on rat and rabbit models with injured ligaments has shown improved biomechanical properties and histological healing when IGF-1 is administered directly to the injury site. However, clinical evidence in humans is limited and mostly indirect. While IGF-1 is sometimes explored as part of biologic or regenerative medicine approaches (such as platelet-rich plasma, which contains growth factors including IGF-1), there are currently no large, high-quality clinical trials that confirm its efficacy or safety for ligament healing in humans. The majority of supportive data comes from basic science and animal research, and the translation to clinical practice remains experimental. Thus, while scientific rationale and preclinical evidence exist, the use of IGF-1 for torn or injured ligaments is not yet established in standard medical practice and should be considered investigational.

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