Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Proline is a non-essential amino acid that plays a key structural role in the synthesis of collagen, the primary protein in connective tissues such as ligaments, tendons, and skin. Scientific rationale for using proline to support ligament healing is based on its biological role: proline-rich sequences are crucial for the stability and function of collagen fibers. Some in vitro and animal studies have shown that proline supplementation can support collagen synthesis and improve wound healing. However, direct human clinical evidence specifically showing that oral proline supplementation accelerates healing of torn or injured ligaments is limited or lacking. Most available human data are extrapolated from broader studies on wound healing or joint health, not ligament-specific injuries. Proline is commonly included in dietary supplements marketed for joint and connective tissue support, often alongside other amino acids or collagen peptides, but the evidence for efficacy in ligament repair is not robust. Therefore, while the scientific basis for proline’s potential role exists due to its involvement in collagen biosynthesis, the direct clinical evidence supporting its use for ligament injuries is modest and more rigorous human trials are needed.

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