Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha lipoic acid (ALA) is a naturally occurring antioxidant that has garnered attention for its potential role in supporting liver detoxification. While there is some scientific rationale for its use, the strength of evidence is moderate and primarily based on preclinical studies, small clinical trials, and its established use as an antidote in certain cases of poisoning (such as mushroom poisoning with Amanita phalloides). ALA functions as both a direct free radical scavenger and a cofactor in mitochondrial energy metabolism. It can regenerate other antioxidants like glutathione, vitamin C, and vitamin E, which are important in hepatic detoxification processes.

Studies in animal models have shown that ALA can protect liver cells from oxidative stress, reduce inflammation, and improve markers of liver injury in chemically-induced liver damage. Human data are more limited. Some small clinical trials have suggested that ALA supplementation may improve liver enzyme levels in people with non-alcoholic fatty liver disease (NAFLD) and may be beneficial in diabetic patients with liver dysfunction.

However, large-scale, high-quality human clinical trials are lacking, and ALA is not universally accepted as a primary treatment for liver detoxification in mainstream medicine. Its use is sometimes incorporated into integrative or complementary medicine protocols, often along with other antioxidants and lifestyle modifications. Overall, while there is a scientific basis for the use of ALA in supporting liver detoxification, more robust evidence is needed for definitive recommendations.

More about alpha lipoic acid
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Other ingredients used for Liver Detoxification

Other health conditions supported by alpha lipoic acid

Products containing alpha lipoic acid

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