Evidence supporting the use of: Berberine
For the health condition: Liver Detoxification

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Berberine is a bioactive compound extracted from several plants used in traditional Chinese and Ayurvedic medicine. In recent years, scientific studies have explored its effects on liver health, particularly regarding "liver detoxification." While "detoxification" is a broad and somewhat non-specific term, research has examined berberine’s impact on liver function and its potential to mitigate liver injury from toxins or metabolic disturbances. Preclinical studies (mainly in animals and cell cultures) suggest berberine can reduce oxidative stress, inflammation, and fat accumulation in the liver. It appears to modulate pathways involved in phase I and phase II detoxification enzymes, and also demonstrates protective effects in models of chemical-induced liver injury (e.g., by carbon tetrachloride or alcohol). However, robust clinical trials in humans specifically evaluating berberine for "liver detoxification" are limited. Some small studies show improvements in markers of liver health (such as ALT, AST, and fatty liver indices) in metabolic syndrome or NAFLD patients. These findings suggest possible benefit, but they do not directly reflect enhanced detoxification capacity in the clinical sense. Overall, while there is some scientific rationale and preliminary evidence for berberine's hepatoprotective effects, the evidence supporting its use specifically for "liver detoxification" is weak and largely extrapolated from related liver health benefits, rather than direct clinical trials focused on detoxification.

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Other ingredients used for Liver Detoxification

Achyranthes
Adzuki bean
Agrimonia pilosa
Agrimony
AHCC
Akebia
Albizia
Albumin
Alfalfa
Algae
Alisma
Allium tuberosum
Allyl sulfide
Aloe vera
alpha-ketoglutarate (AKG)
alpha-lipoic acid
Alstonia scholaris
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amino acids
Amor seco
anamu
Andrographis
andrographolide
anemarrhena asphodeloides
ankaflavin
anthocyanins
anthraquinone
Antrodia camphorata
apigenin
apple
Appleblossom Cassia
apricot
Ardisia
arjun tree
arjuna
Arjunolic acid
artichoke
Asam gelugor
ashitaba
asparagus
astragalin
astragaloside
astragalus
atractylone
aucubin
avocado
Baccharoides anthelmintica
bacteria
bael
baicalein
Baikal Skullcap
balsam
banyan
barberry
Barleria
barley
Basidiomycota
Bassia scoparia
BCAA
Beef liver
beet
belleric myrobalan
benzyl isothiocyanate
berberine
Berberis (unspecified)
Bergenia
bergenin
beta caryophyllene
betel
Bifidobacteria
bignay
bile salt
biota seed
birch
bitter principals
black cumin
black garlic
black gram
black nightshade
black root
black seed
blackthorn
Blepharis
blue flag
boldo
borotutu
bottle gourd
bovine liver
branched-chain amino acids
Brassica
Bupleurum
bupleurum falcatum
burdock
butternut
C-phycocyanin
cabbage
calamus
capers
carqueja
Carthamus
cascara sagrada
catalase
caterpillar mushroom
celandine
Centaurium erythraea
centaury
Centella asiatica
chaga mushroom
chanca piedra
chebulic acid
chebulinic acid
chicory
Chinese fleeceflower
Chinese Ligustrum berry
Chinese pond turtle
Chinese salvia root
Chinese silkvine
chirata
chlorella
chokeberry
cholic acid
chrysanthemum
cinnamic acid
cinnamon
cleavers
Clerodendrum indicum
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Clerodendrum phlomidis
coix
copalchi
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cordyceps
coriander
corilagin
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coumaric acid
cruciferous
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curcumin
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cynaropicrin
Cynodon dactylon
d-glucarate
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diallyl sulfide
dihydromyricetin
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duckweed
ellagic acid
ellagitannin
Embelia
emblicanin
emodin
endive
Enicostemma littorale
epigallocatechin gallate (EGCG)
Erodium cicutarium
Ficus religiosa
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flavanones
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fo-ti
fucoidan
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fumitory
gallate
gallic acid
gamma-glutamylcysteine
ganoderma
garden cress
gardenia
Gardenia jasminoides
genipap
gentian root
Gentiana macrophylla
ginger
Glucaric acid
Glucoraphanin
Glucuronic acid
Glutathione
Glycine
Glycophospholipid
Glycosaponin
Glycyrrhizin
goji berry
golden shower tree
goldenrod
gooseberry
green chiretta
green tea
Gypenoside
Hemidesmus
hibiscus
Homalomena
honeysuckle
horse gram
Hygrophila
Indian frankincense
Indian gum arabic tree
Indian nightshade
Indian sarsparilla
indole-3-carbinol
iridoids
isosilybin
isothiocyanates
Jatoba
Java tea
Job\'s tears
jujube
Jurubeba
kale
knotgrass
knotweed
Kokam
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kuding tea
kudzu
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L-cysteine
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L-ornithine
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licorice root
Ligustrum
limonene
Lindera
lingzhi
liquid liver fractions
little ironweed
liverwort
lophatherum leaf
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loquat
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lovage
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noni
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oleanolic acid
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orange
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ornithine L-aspartic acid
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Osthole
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paeoniflorin
perilla
phosphatidylcholine
phospholipids
picrorhiza kurroa
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pollen
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quercetin
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Rhamnus nakaharai
rhubarb
rhubarb root
Ribose-l-cysteine
Rooibos
root tuber
rosmarinic acid
rosthorn snake gourd
Rubia cordifolia
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Rumex acetosa
S-Methylmethionine
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SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
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seaweed
selenium
Selenocysteine
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sheep's sorrel
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smilax
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soursop
spirulina
Stachytarpheta cayennensis
Stone Root
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Swertia
Syringic acid
Szechuan lovage
Tanshinone
Taraxacin
Taraxacum
Taraxasterol
Taraxol
Taurochenodeoxycholic acid
Taurocholic acid
Taurodeoxycholic acid
Terminalia
Theabrownin
Thistle
Tinospora cordifolia
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Tumerone
turmeric
typhonium
Ursolic Acid
vegetable and fruit blend (proprietary)
Vine tea
vitamin B6
vitamin C
vitamin E
Walnut
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wheat grass
Whey protein
Withanolides
Xanthorrhizol
Yellow Dock
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Yin Chen
Yuzu
Zinc
Zingerone