Evidence supporting the use of: Diindolylymethane
For the health condition: Liver Detoxification
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Diindolylmethane (DIM) is a compound formed in the body during the digestion of indole-3-carbinol, a substance found in cruciferous vegetables like broccoli and Brussels sprouts. Its use for liver detoxification is primarily supported by early-stage scientific evidence, although robust clinical data in humans are limited. Most research focuses on DIM’s ability to modulate estrogen metabolism by promoting the formation of less potent estrogen metabolites, which are more easily excreted by the liver. This has led to the hypothesis that DIM supports liver detoxification, particularly of hormones and certain toxins.
Animal and in vitro studies suggest that DIM can induce phase I and phase II detoxification enzymes in the liver, such as cytochrome P450 enzymes and glutathione S-transferases. These enzymes are involved in the metabolism and clearance of various endogenous and exogenous compounds. However, direct clinical trials in humans demonstrating improved liver detoxification function or clinical outcomes are rare.
Overall, while DIM has plausible mechanisms for supporting aspects of liver detoxification, especially estrogen metabolism, the strength of scientific evidence in humans is modest. The evidence is primarily preclinical, with a few small human studies suggesting a potential role. More large-scale, controlled human trials are needed to confirm its efficacy and safety for this specific use.
More about Diindolylymethane
More about Liver Detoxification
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alfalfaaloe vera
alpha-ketoglutarate (AKG)
amino acids
green chiretta
anthocyanins
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cucumber
turmeric
curcumin
cuspidatum root
d-glucarate
dandelion
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milk thistle
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niacinamide (vitamin B3)
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Baicalein
Bael
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Basidiomycota
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Banyan
Black Nightshade
Bitter principals
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Other health conditions supported by Diindolylymethane
Cancer (natural therapy for)Cancer (prevention)
Cancer Treatment (reducing side effects)
Fibroids (uterine)
Inflammation
Liver Detoxification
Menopause
PMS (general)