Evidence supporting the use of: Dithiolthiones
For the health condition: Liver Detoxification
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Dithiolthiones, such as 1,2-dithiole-3-thione (D3T) and oltipraz, are sulfur-containing compounds that have been investigated for their potential to support liver detoxification. Their use is primarily justified by scientific research rather than tradition. Several preclinical and limited clinical studies have shown that dithiolthiones can induce phase II detoxification enzymes, especially glutathione S-transferases (GSTs), in the liver. These enzymes play a crucial role in conjugating and eliminating toxins and carcinogens.
Oltipraz, for example, has been studied as a chemopreventive agent because it increases the expression of detoxification enzymes and protects against chemically induced liver damage in animal models. Some early phase clinical trials in humans have suggested that oltipraz can modulate these detoxification pathways, but robust clinical evidence for its efficacy in general liver "detoxification" or in treating liver disease is lacking. The evidence supporting the use of dithiolthiones for liver detoxification is primarily mechanistic and preclinical, with moderate support from small human trials focusing on specific toxin exposures rather than general health claims.
In summary, dithiolthiones have a scientific rationale for supporting liver detoxification processes at the biochemical level, but the clinical evidence for broad use in liver detoxification or disease treatment remains limited. More large-scale, controlled human studies are needed to fully validate their efficacy and safety for this purpose.
Other ingredients used for Liver Detoxification
AchyranthesAdzuki bean
Agrimonia pilosa
Agrimony
AHCC
Akebia
Albizia
Albumin
Alfalfa
Algae
Alisma
Allium tuberosum
Allyl sulfide
Aloe vera
alpha-ketoglutarate (AKG)
alpha-lipoic acid
Alstonia scholaris
American Liverleaf
amino acids
Amor seco
anamu
Andrographis
andrographolide
anemarrhena asphodeloides
ankaflavin
anthocyanins
anthraquinone
Antrodia camphorata
apigenin
apple
Appleblossom Cassia
apricot
Ardisia
arjun tree
arjuna
Arjunolic acid
artichoke
Asam gelugor
ashitaba
asparagus
astragalin
astragaloside
astragalus
atractylone
aucubin
avocado
Baccharoides anthelmintica
bacteria
bael
baicalein
Baikal Skullcap
balsam
banyan
barberry
Barleria
barley
Basidiomycota
Bassia scoparia
BCAA
Beef liver
beet
belleric myrobalan
benzyl isothiocyanate
berberine
Berberis (unspecified)
Bergenia
bergenin
beta caryophyllene
betel
Bifidobacteria
bignay
bile salt
biota seed
birch
bitter principals
black cumin
black garlic
black gram
black nightshade
black root
black seed
blackthorn
Blepharis
blue flag
boldo
borotutu
bottle gourd
bovine liver
branched-chain amino acids
Brassica
Bupleurum
bupleurum falcatum
burdock
butternut
C-phycocyanin
cabbage
calamus
capers
carqueja
Carthamus
cascara sagrada
catalase
caterpillar mushroom
celandine
Centaurium erythraea
centaury
Centella asiatica
chaga mushroom
chanca piedra
chebulic acid
chebulinic acid
chicory
Chinese fleeceflower
Chinese Ligustrum berry
Chinese pond turtle
Chinese salvia root
Chinese silkvine
chirata
chlorella
chokeberry
cholic acid
chrysanthemum
cinnamic acid
cinnamon
cleavers
Clerodendrum indicum
Clerodendrum indicum
Clerodendrum phlomidis
coix
copalchi
Coptis chinensis
cordyceps
coriander
corilagin
coriolus mushroom
corktree
couch grass
coumaric acid
cruciferous
cucumber
curcumin
cuspidatum root
Cyathula
cynarin
cynaropicrin
Cynodon dactylon
d-glucarate
dandelion
deoxyandrographolides
Desmodium
diallyl disulfide (DADS)
diallyl sulfide
dihydromyricetin
dithiolthiones
DL-Methionine
duckweed
ellagic acid
ellagitannin
Embelia
emblicanin
emodin
endive
Enicostemma littorale
epigallocatechin gallate (EGCG)
Erodium cicutarium
Ficus religiosa
Ficus simplicissima
flavanones
flavans
flavonolignan
flavonones
Flueggea suffruticosa
fo-ti
fucoidan
Fumaria parviflora
fumitory
gallate
gallic acid
gamma-glutamylcysteine
ganoderma
garden cress
gardenia
Gardenia jasminoides
genipap
gentian root
Gentiana macrophylla
ginger
Glucaric acid
Glucoraphanin
Glucuronic acid
Glutathione
Glycine
Glycophospholipid
Glycosaponin
Glycyrrhizin
goji berry
golden shower tree
goldenrod
gooseberry
green chiretta
green tea
Gypenoside
Hemidesmus
hibiscus
Homalomena
honeysuckle
horse gram
Hygrophila
Indian frankincense
Indian gum arabic tree
Indian nightshade
Indian sarsparilla
indole-3-carbinol
iridoids
isosilybin
isothiocyanates
Jatoba
Java tea
Job\'s tears
jujube
Jurubeba
kale
knotgrass
knotweed
Kokam
Kombucha
kuding tea
kudzu
Kutkins
L-cysteine
L-glutathione
L-methionine
L-ornithine
Lentinula edodes mycelia
Leptadenia
licorice root
Ligustrum
limonene
Lindera
lingzhi
liquid liver fractions
little ironweed
liverwort
lophatherum leaf
Lophira lanceolata
loquat
Loranthus
lotus seed
lovage
Lycium
Maclura tricuspidata
Mesua
Milk thistle
Millettia
Mondo grass
Moringa
Morus
Mulberry
Mung bean
Myrobalan
Myrosinase
Myrrh
Nardostachys
Naringin
Neem tree
Nettle
Niacinamide (vitamin B3)
noni
Oldenlandia diffusa
oleanolic acid
Operculina turpethum
orange
Ornithine
ornithine L-aspartic acid
Osmanthus
Osthole
Oxymatrine
paeoniflorin
perilla
phosphatidylcholine
phospholipids
picrorhiza kurroa
Picroside
Plectranthus amboinicus
Pleurotus eryngii
pollen
Polygonatum
Polygonum
Polyporus
polysaccharides
Premna
Prickly Pear Cactus
pu-er tea
pumpkin
purslane
Qin Jiao
quercetin
radish
reishi mushroom
Rhamnus nakaharai
rhubarb
rhubarb root
Ribose-l-cysteine
Rooibos
root tuber
rosmarinic acid
rosthorn snake gourd
Rubia cordifolia
Rubia yunnanensis
Rubiaceae
Rumex acetosa
S-Methylmethionine
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Sargassum
Sarivan
sarsaparilla
Scabrous Gentian
Schisandrins
Schizandrol A
Scirpus
Scoparia dulcis
Scopoletin
seaweed
selenium
Selenocysteine
Selenomethionine
Semecarpus anacardium
sheep's sorrel
Silybin
Silybum
Silychristin
Silydianin
silymarin
smilax
Solanum anguivi
soursop
spirulina
Stachytarpheta cayennensis
Stone Root
Sulforaphane
Sweet Woodruff
Swertia
Syringic acid
Szechuan lovage
Tanshinone
Taraxacin
Taraxacum
Taraxasterol
Taraxol
Taurochenodeoxycholic acid
Taurocholic acid
Taurodeoxycholic acid
Terminalia
Theabrownin
Thistle
Tinospora cordifolia
Trametes
Tumerone
turmeric
typhonium
Ursolic Acid
vegetable and fruit blend (proprietary)
Vine tea
vitamin B6
vitamin C
vitamin E
Walnut
Wasabi
Watercress
Watermelon
Wax Gourd
wheat grass
Whey protein
Withanolides
Xanthorrhizol
Yellow Dock
Yellow-Fruit Nightshade
Yin Chen
Yuzu
Zinc
Zingerone
Other health conditions supported by dithiolthiones
Cancer (natural therapy for)Cancer (prevention)
Cancer Treatment (reducing side effects)
Chemotherapy (reducing side effects)
Fatty Liver Disease
Inflammation
Liver Detoxification
Radiation Sickness