Evidence supporting the use of: Limonene
For the health condition: Liver Detoxification

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Limonene, a major component of citrus essential oils, has been investigated for its potential role in supporting liver detoxification. Preclinical research, primarily in animal models and in vitro studies, indicates that limonene may exert hepatoprotective effects. These effects include the enhancement of phase I and phase II liver detoxification enzymes, such as cytochrome P450s and glutathione S-transferases, which are involved in the metabolism and clearance of xenobiotics and toxins. Furthermore, limonene has demonstrated antioxidant and anti-inflammatory properties that may contribute to protection against liver damage induced by toxins like carbon tetrachloride and acetaminophen in animal studies.

However, direct clinical evidence in humans supporting limonene’s efficacy for liver detoxification is limited. Most of the available data are derived from laboratory and animal studies, with only a few human studies focusing on other potential benefits of limonene, such as its anti-cancer or digestive effects. There is also a lack of standardized protocols and dosages for its use in liver detoxification. As such, while the mechanistic and preclinical evidence is promising, the overall quality and quantity of human data remain insufficient to strongly support its use for this specific purpose.

In summary, limonene’s use for liver detoxification is supported by early scientific research, but conclusive evidence from human clinical trials is lacking. More research is needed to establish safety, efficacy, and appropriate dosing in this context.

More about Limonene
More about Liver Detoxification

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Products containing Limonene

We currently have no products on Vitabase that contain this ingredient.