Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin is a flavonoid found in many fruits and vegetables and is recognized for its antioxidant and anti-inflammatory properties. Scientific research has explored its potential role in supporting liver health, particularly in the context of liver detoxification and protection against liver injury. Preclinical studies (in vitro and animal models) have shown that quercetin can modulate key detoxification enzymes in the liver, such as those involved in Phase I and Phase II metabolism (e.g., cytochrome P450 enzymes, glutathione S-transferases). Additionally, quercetin has demonstrated hepatoprotective effects in animal models subjected to various liver toxins, reducing oxidative stress, lipid peroxidation, and inflammatory signaling. However, human clinical studies directly assessing quercetin’s effect on liver detoxification or its therapeutic benefit in liver diseases are limited and often underpowered. Some small-scale human trials suggest quercetin supplementation may improve markers of liver function in individuals with non-alcoholic fatty liver disease (NAFLD) or metabolic syndrome, but the evidence remains preliminary. There is currently insufficient high-quality evidence to support the use of quercetin as a primary agent for liver detoxification in humans, and its use is mainly based on extrapolation from laboratory and animal studies. In summary, while there is some scientific rationale for quercetin’s liver-supporting properties, robust clinical trial evidence is lacking, and its role in liver detoxification in humans has not been firmly established.

More about quercetin
More about Liver Detoxification

Other ingredients used for Liver Detoxification

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