Synopsis

Source of validity: Scientific
Rating (out of 5): 4

S-adenosylmethionine (SAMe) is a compound naturally produced in the body that plays a key role in methylation processes and the synthesis of glutathione, a critical antioxidant for liver detoxification. Several clinical studies and reviews support the use of SAMe in liver disorders, especially in the context of cholestatic liver diseases (such as intrahepatic cholestasis of pregnancy and primary biliary cholangitis). SAMe has been shown to increase hepatic glutathione levels, which can help protect liver cells from toxins and oxidative stress. Randomized controlled trials and meta-analyses indicate that SAMe supplementation can improve biochemical markers of liver function (such as bilirubin and transaminases) and may alleviate symptoms in patients with liver dysfunction. However, while most data relate to specific liver diseases, some evidence also suggests a potential benefit for general hepatic detoxification, largely due to its role in promoting glutathione synthesis and supporting methylation pathways. The use of SAMe is not primarily based on traditional medicine but rather on biochemical rationale and clinical study findings. While SAMe is not a cure for liver disease, its supportive role in liver detoxification processes is scientifically validated, particularly for improving liver function in certain conditions. More research is needed for its efficacy in general "detoxification" in healthy individuals.

More about SAMe
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Other ingredients used for Liver Detoxification

alfalfa
aloe vera
alpha-ketoglutarate (AKG)
amino acids
green chiretta
anthocyanins
apple
apricot
arjun tree
artichoke
asparagus
astragalus
barberry
barley
beet
myrobalan
berberine
beta caryophyllene
betel
black cumin
black garlic
radish
Indian frankincense
bovine liver
branched-chain amino acids
bupleurum falcatum
burdock
catalase
caterpillar mushroom
chaga mushroom
chicory
Chinese salvia root
chlorella
chokeberry
cinnamon
Coptis chinensis
cordyceps
cucumber
turmeric
curcumin
cuspidatum root
d-glucarate
dandelion
diallyl disulfide (DADS)
epigallocatechin gallate (EGCG)
gardenia
gentian root
ginger
gooseberry
green tea
hibiscus
Indian gum arabic tree
indole-3-carbinol
honeysuckle
knotweed
jujube
kale
kudzu
l-cysteine
l-glutathione
l-methionine
l-ornithine
lentinula edodes mycelia
licorice root
liquid liver fractions
lophatherum leaf
lovage
milk thistle
moringa
naringin
nettle
niacinamide (vitamin B3)
oleanolic acid
orange
perilla
phosphatidylcholine
phospholipids
pollen
pumpkin
quercetin
redcurrant
reishi mushroom
rhubarb root
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
selenium
silymarin
spirulina
vegetable and fruit blend (proprietary)
vitamin B6
vitamin C
vitamin E
seaweed
wasabia japonica
watercress
watermelon
wheat grass
whey protein
mulberry
zinc
sarsaparilla
cascara sagrada
typhonium
neem tree
enicostemma littorale
clerodendrum indicum
smilax
tinospora cordifolia
fumaria parviflora
picrorhiza kurroa
rubia cordifolia
swertia
lingzhi
lingusticum wallichii
goldenrod
bile salt
morus
myrrh
root tuber
chrysanthemum
ganoderma
lotus seed
birch
couch grass
sheep's sorrel
anemarrhena asphodeloides
purslane
coix
polyporus
gentiana macrophylla
cleavers
noni
biota seed
goji berry
algae
ashitaba
soursop
Arjuna
akebia
Ankaflavin
Anthraquinone
Ardisia
Agrimony
Apigenin
Antrodia camphorata
Achyranthes
Anamu
Albizia
AHCC
Aucubin
Andrographolide
Avocado
Albumin
American Liverleaf
Appleblossom Cassia
Asam gelugor
Alpha-Lipoic Acid
Astragaloside
Andrographis
Adzuki bean
Alsonia scholaris
Agrimonia pilosa
Allyl Sulfide
Alisma
Allium tuberosum
Amor seco
Arjunolic acid
Astragalin
Atractylone
Black Seed
Baikal Skullcap
Blue Flag
Borotutu
Blackthorn
bergenin
Blepharis
Balsam
Brassica
Belleric myrobalan
Beef liver
Barleria
Berberis (unspecified)
Baicalein
Bael
Butternut
Basidiomycota
boldo
Black Gram
Baccharoides anthelmintica
Banyan
Black Nightshade
Bitter principals
Bacteria
Black root
Bifidobacteria
BCAA
Bupleurum
benzyl isothiocyanate
Bassia scoparia
Bergenia
Bignay
Bottle gourd
Centaury
Chinese Silkvine
cholic acid
Carqueja
Chebulic acid
Coriolus mushroom
Coriander
Clerodendrum phlomidis
Centaurium erythraea
Cyathula
Chinese Fleeceflower
Cynarin
Chinese Pond Turtle
Cruciferous
Centella asiatica
Capers
Chanca Piedra
Celandine
Cinnamic Acid
Chinese Ligustrum berry
Copalchi
Corktree
C-Phycocyanin
Cabbage
Chirata
Calamus
Chebulinic acid
Corilagin
Coumaric acid
Cynaropicrin
Cynodon dactylon
Carthamus
Clerodendrum indicum
Diallyl sulfide
Dihydromyricetin
DL-Methionine
Deoxyandrographolides
Dithiolthiones
Desmodium
Duckweed
Ellagic Acid
Erodium cicutarium
Emblicanin
Endive
Embelia
Ellagitannin
Emodin
Flavonones
Glycine
Little ironweed
Prickly Pear Cactus
Rhubarb
walnut

Other health conditions supported by SAMe

Alzheimer's Disease
Depression
Fibromyalgia Syndrome
Liver Detoxification

Products containing SAMe

We currently have no products on Vitabase that contain this ingredient.