Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Selenium is an essential trace mineral that plays a key role in the function of several antioxidant enzymes, most notably glutathione peroxidases. These enzymes are crucial for protecting cells from oxidative damage by neutralizing harmful free radicals and peroxides, processes that are particularly active in the liver due to its central role in detoxification. Scientific studies have demonstrated that selenium deficiency can impair liver function and increase susceptibility to oxidative stress and toxin-induced liver injury. Animal and human studies have shown that selenium supplementation can mitigate liver damage in various models of toxicity (such as alcohol, drugs, or heavy metals), largely through enhancement of antioxidant defenses. Specifically, selenium supports phase II detoxification by maintaining adequate levels of glutathione, a primary detoxifying agent in the liver. However, while there is substantial mechanistic and experimental support, evidence from large-scale, high-quality human clinical trials specifically examining selenium supplementation for improving liver detoxification in healthy individuals or patients with chronic liver disease is limited. Most existing research supports selenium’s role in general liver health and protection against certain toxic insults, rather than in promoting routine "liver detox" as marketed in wellness contexts. Overall, the scientific evidence supports selenium’s supportive role in liver function due to its involvement in antioxidant defense, but more targeted clinical studies are needed to fully validate its use for liver detoxification in humans.

More about selenium
More about Liver Detoxification

Other ingredients used for Liver Detoxification

Other health conditions supported by selenium

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