Evidence supporting the use of: Selenocysteine
For the health condition: Liver Detoxification

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Selenocysteine, known as the 21st amino acid, is the biologically active form of selenium incorporated into selenoproteins, many of which play critical roles in antioxidant defense and detoxification processes in the liver. The liver expresses several important selenoproteins, such as glutathione peroxidases (GPxs) and thioredoxin reductases, which help neutralize reactive oxygen species and protect cells from oxidative stress, particularly during the metabolism of drugs and toxins.

Multiple animal and in vitro studies have demonstrated that selenium deficiency impairs liver function and increases susceptibility to oxidative injury. Supplementation with selenium, including forms that yield selenocysteine, has been shown to enhance the activity of hepatic antioxidant enzymes and may reduce the severity of chemically-induced liver damage in animal models. Some human studies indicate that individuals with chronic liver diseases may have lower selenium levels, and supplementation can improve certain biomarkers of liver function and oxidative status, though evidence of clinical efficacy in disease outcomes is limited and inconsistent.

Overall, the use of selenocysteine or selenium compounds for liver detoxification is grounded in a scientific understanding of selenoprotein biology and supported by moderate preclinical evidence. However, robust, large-scale clinical trials demonstrating clear benefits in humans are lacking, and thus the evidence is best rated as moderate (3/5).

More about Selenocysteine
More about Liver Detoxification

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Products containing Selenocysteine

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