Evidence supporting the use of: Vitamin B6 (pyridoxal 5-phosphate)
For the health condition: Liver Detoxification

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6, particularly in its active form pyridoxal 5'-phosphate (PLP), has some scientific basis for supporting liver detoxification, but the evidence is limited and not robust. B6 is a critical coenzyme in numerous metabolic processes, including amino acid metabolism, neurotransmitter synthesis, and the functioning of the transsulfuration pathway. The transsulfuration pathway is significant in liver detoxification because it helps convert homocysteine to cysteine, which is then used for glutathione synthesis. Glutathione is a major antioxidant and detoxifying molecule in the liver, playing a central role in phase II detoxification processes. Some studies have shown that B6 deficiency can impair glutathione production and compromise antioxidant defenses in the liver. Animal studies and a few human observational studies indicate that adequate B6 status is associated with better liver function and reduced markers of oxidative stress. However, there is a lack of direct clinical trials demonstrating that B6 supplementation alone significantly enhances liver detoxification in humans, especially in the absence of deficiency. Most evidence comes from mechanistic studies or broader research on B vitamins in liver health and not from targeted intervention trials. In summary, while there is a biological rationale and some scientific support for the role of B6 in liver detoxification pathways, especially due to its involvement in glutathione synthesis, high-quality clinical evidence specifically validating B6 supplementation for liver detoxification is limited.

More about Vitamin B6 (pyridoxal 5-phosphate)
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green tea
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Products containing Vitamin B6 (pyridoxal 5-phosphate)

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