The use of Ficus simplicissima for treating or supporting swollen lymph nodes or glands is primarily rooted in traditional medicine practices rather than scientific validation. In some regions of Southeast Asia, various species of Ficus have been used in folk remedies for inflammatory conditions, including swellings that may involve the lymph nodes or glands. Ethnobotanical surveys have documented the use of Ficus simplicissima and related species in poultices and decoctions applied externally or consumed to address swellings, abscesses, and generalized inflammation. However, these uses are often generalized for swelling and not specifically targeted at lymphatic conditions as understood in modern medicine.

To date, there is extremely limited scientific research specifically examining the efficacy of Ficus simplicissima for swollen lymph nodes or glands. Some laboratory studies on related Ficus species have identified anti-inflammatory and antimicrobial properties in various extracts, but these findings cannot be directly extrapolated to lymphadenopathy in humans. There is no clinical trial evidence or mechanistic study supporting the use of Ficus simplicissima for this indication. As such, the evidence rating is low, reflecting that its use is primarily based on local or traditional beliefs and not on rigorous scientific validation.