Evidence supporting the use of: Oldenlandia diffusa
For the health condition: Lymph Nodes or Glands (swollen)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Oldenlandia diffusa (also known as Hedyotis diffusa) has a long history of use in Traditional Chinese Medicine (TCM) for treating conditions involving "heat" and "toxicity," including swollen lymph nodes and glands, often associated with infections or inflammatory conditions. In TCM, it is commonly used as part of herbal formulas (such as "Bai Hua She She Cao") for abscesses, sore throats, and lymphadenitis. The herb is believed to have "heat-clearing" and "detoxifying" properties, and practitioners have traditionally prescribed it for swellings due to its purported anti-inflammatory and antimicrobial effects.

Scientific research on Oldenlandia diffusa has mainly focused on its anticancer, anti-inflammatory, and immunomodulatory activities. Several in vitro and animal studies suggest it contains compounds (such as iridoid glycosides and flavonoids) with anti-inflammatory and cytotoxic properties. However, direct clinical evidence supporting its efficacy specifically for swollen lymph nodes or lymphadenitis in humans is lacking. Most available studies are either preclinical or do not focus explicitly on lymphatic conditions. Therefore, while its use is strongly supported by traditional practice, the scientific evidence remains preliminary and indirect.

In summary, Oldenlandia diffusa is traditionally used for swollen lymph nodes and glands, but robust clinical validation is not yet available. Its use for this indication is justified mainly by traditional rather than scientific evidence.

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