Evidence supporting the use of: Triterpene Saponin
For the body system: Lymphatics

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Triterpene saponins are naturally occurring compounds found in a variety of plants, including well-known medicinal herbs like ginseng (Panax spp.), licorice (Glycyrrhiza spp.), and horse chestnut (Aesculus hippocastanum). Their use in traditional medicine to support lymphatic health is primarily based on historical and ethnobotanical practices rather than robust scientific validation. In particular, horse chestnut extracts, rich in triterpene saponins such as aescin, have been used traditionally to treat chronic venous insufficiency and related symptoms like swelling and edema, which can involve lymphatic dysfunction. Some preliminary studies suggest that these saponins may help reduce capillary permeability and improve venous tone, potentially offering indirect support to lymphatic drainage. However, direct, high-quality clinical evidence specifically demonstrating triterpene saponins’ benefits for lymphatic system function is limited. Most available research focuses on the vascular system rather than the lymphatic system itself. As a result, while traditional use supports their inclusion in remedies for lymphatic and circulatory health, scientific backing remains modest and indirect. For this reason, the overall strength of evidence is rated at 2 out of 5, reflecting traditional use with some suggestive, but not definitive, scientific support.

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