Wild Indigo (Baptisia tinctoria) has a long-standing traditional use in Western herbalism, especially for supporting the lymphatic system. Herbalists have historically used Wild Indigo as an immune stimulant and for its purported ability to help the body cope with infections, particularly those involving swollen lymph nodes, sore throats, and septic conditions. The rationale behind its use is its reputation as an "alterative"—a class of herbs believed to gradually restore health and proper function to the body, including the lymphatic system.

There is limited scientific research directly validating Wild Indigo’s effects on the lymphatic system. Most available evidence consists of anecdotal reports and traditional herbal literature, such as those written by Eclectic physicians in the 19th and early 20th centuries, who noted its use in cases of lymphatic congestion and as an adjunct in treating infections. A few laboratory studies suggest that Baptisia species may have mild immunomodulatory and antimicrobial properties, but these findings are preliminary and do not directly confirm benefits for lymphatic health in humans.

In summary, the use of Wild Indigo to support the lymphatic system is primarily justified by traditional use, with a modest level of supporting evidence, and little to no robust modern clinical research.