Evidence supporting the use of: Cytokines
For the health condition: Lymphoma

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Cytokines, specifically certain types such as interferons (e.g., interferon-alpha) and interleukins (e.g., interleukin-2), have been scientifically validated as therapeutic agents in the treatment of some lymphomas. These proteins are naturally occurring signaling molecules in the immune system that can modulate immune responses against cancer cells. Their use is based on robust scientific research, including clinical trials and long-term studies. For example, interferon-alpha has been used as a treatment for several types of non-Hodgkin lymphoma, such as follicular lymphoma and hairy cell leukemia. Clinical trials in the 1980s and 1990s demonstrated that interferon-alpha can induce remissions and prolong survival in selected patients. The mechanism involves stimulating the immune system to attack lymphoma cells and possibly inhibiting tumor cell proliferation directly. Similarly, interleukin-2 has been explored in combination therapies for aggressive lymphomas, aiming to boost the activity of cytotoxic T cells and natural killer (NK) cells against malignant cells. Despite these benefits, cytokine therapy is often limited by significant side effects and the development of more effective, better-tolerated treatments, such as monoclonal antibodies and targeted therapies. Nonetheless, the use of cytokines in lymphoma is scientifically validated, with a base of clinical research supporting their efficacy, particularly in certain subtypes or refractory cases.

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