Evidence supporting the use of: Artemether
For the health condition: Malaria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Artemether is a well-established antimalarial agent with strong scientific evidence supporting its use. It is a semi-synthetic derivative of artemisinin, a compound originally isolated from the sweet wormwood plant (Artemisia annua), which has been used in traditional Chinese medicine for centuries to treat fever and malaria. Artemether acts rapidly against the asexual erythrocytic stages of Plasmodium species, including P. falciparum, the most dangerous malaria parasite. Its mechanism involves production of free radicals within the parasite, leading to damage of parasite proteins and membranes.

Numerous randomized controlled trials and meta-analyses have demonstrated that artemether, particularly when combined with lumefantrine (in artemether-lumefantrine, or AL), is highly effective in treating uncomplicated malaria and is recommended by the World Health Organization (WHO) as a first-line therapy. Artemether is especially valuable in regions with chloroquine-resistant malaria. Its efficacy, rapid parasite clearance, and relatively favorable safety profile are well documented in the scientific literature.

In conclusion, the use of artemether to treat malaria is supported by robust, high-quality evidence, as well as endorsement from major health authorities globally. Its development represents a major advance in the treatment of malaria, particularly in areas where resistance to other antimalarials is prevalent.

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Other health conditions supported by Artemether

Malaria

Products containing Artemether

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