Evidence supporting the use of: Black nightshade
For the health condition: Malaria

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Black Nightshade (Solanum nigrum) has a long history of use in traditional medicine across various cultures, especially in Africa and Asia. In some regions, it has been employed as part of herbal remedies for fever and symptoms associated with malaria. The rationale for its use is largely based on its general antipyretic (fever-reducing) and anti-inflammatory properties described in ethnobotanical records. Some traditional healers have used decoctions of Black Nightshade leaves or berries with the intent to alleviate malaria symptoms, not necessarily to cure the infection itself but to manage fever and discomfort.

Regarding scientific evidence, a limited number of in vitro and animal studies have explored the antiplasmodial (anti-malaria parasite) activity of extracts from Solanum nigrum. While some of these studies suggest mild to moderate activity against Plasmodium species (the causative agents of malaria), results have been inconsistent, and the doses required for observable effects are often high. To date, no robust clinical trials in humans have confirmed its efficacy or safety as a treatment for malaria. The evidence supporting its use is therefore mostly traditional, with only preliminary and inconclusive scientific support. Modern malaria treatment relies on well-established antimalarial drugs, and Black Nightshade is not recommended as a substitute or primary therapy.

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