Evidence supporting the use of: Leptadenia
For the health condition: Malaria

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Leptadenia is primarily used against malaria in traditional medicine, particularly in certain African and Indian ethnomedical systems. Several ethnobotanical surveys document the use of Leptadenia species, such as Leptadenia hastata, as part of herbal remedies for malaria. For example, decoctions or infusions of its leaves, stems, or roots are commonly administered for fever and symptoms reminiscent of malaria. However, while traditional use is well-documented, scientific validation remains limited. A few in vitro studies have examined extracts for antiplasmodial activity, but results have been inconsistent or weak compared to standard antimalarial drugs; furthermore, such studies are sparse and often preliminary. To date, no high-quality clinical trials have evaluated Leptadenia’s efficacy for malaria, and its active compounds have not been characterized fully in this context. Therefore, the support for Leptadenia’s use in malaria is based on cultural and historical precedent rather than robust scientific evidence. Researchers caution that, until more rigorous pharmacological and clinical data are available, Leptadenia should not be relied upon as a primary treatment for malaria.

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