Evidence supporting the use of: Aspartic acid
For the body system: Male Reproductive System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Aspartic acid, particularly in the form of D-aspartic acid (DAA), has been investigated for its potential role in supporting the male reproductive system, mainly by influencing testosterone synthesis. Some scientific studies have shown that DAA can temporarily increase testosterone levels in healthy men, especially those with low baseline testosterone or in infertile men. For example, a 2009 study (Topo et al.) found that DAA supplementation increased testosterone and luteinizing hormone levels in both humans and rats. However, later studies, including well-controlled trials in resistance-trained men, have not consistently replicated these findings. Some have shown no effect or even a decrease in testosterone with prolonged use. The mechanism is believed to involve the stimulation of the release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH), which in turn can stimulate testosterone production by the testes. While there is no long-standing traditional use of aspartic acid for male reproductive health, scientific interest remains due to its role as an amino acid and neurotransmitter. Overall, while there is some preliminary scientific evidence supporting the use of DAA for short-term testosterone boosting, the quality and consistency of evidence are limited, and more rigorous studies are needed to confirm efficacy and safety for reproductive health support.

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Male Reproductive System