Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Equol is a metabolite produced in the gut from the isoflavone daidzein, commonly found in soy. Its use in supporting the male reproductive system is scientifically explored, particularly regarding prostate health and androgen regulation. Several clinical and preclinical studies suggest that Equol can bind to dihydrotestosterone (DHT), a potent androgen implicated in benign prostatic hyperplasia (BPH) and male pattern baldness. By binding to DHT, Equol may reduce its activity, potentially benefiting prostate health and reducing symptoms associated with BPH.

For example, a 2012 double-blind, placebo-controlled trial published in The Prostate found that Equol supplementation reduced prostate-specific antigen (PSA) levels in men with elevated PSA, suggesting an effect on prostate health. Other research has shown that Equol can modulate hormone levels and has anti-androgenic effects, which may be beneficial for men experiencing conditions linked to excess DHT.

However, not all men can endogenously produce Equol, and the effects may vary by individual. While preliminary evidence is promising, larger and longer-term clinical studies are needed to firmly establish efficacy and safety. Thus, the evidence is rated as moderate (3/5): there is scientific backing for its use in supporting aspects of male reproductive health, but consensus and robust clinical validation are still developing.

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