Evidence supporting the use of: Folic acid
For the body system: Male Reproductive System
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Folic acid, a synthetic form of the B-vitamin folate, has scientific support for its use in supporting aspects of the male reproductive system, particularly male fertility. Research indicates that folic acid plays a role in DNA synthesis, cell division, and the overall health of sperm. Several studies have found associations between adequate folate status and improved sperm quality, including concentration, motility, and reduced sperm DNA damage. For example, a randomized controlled trial published in Fertility & Sterility (2002) showed that supplementation with folic acid (combined with zinc) significantly increased sperm count in subfertile men. Additionally, a 2017 systematic review in Andrology concluded that folate supplementation may improve certain sperm parameters, especially in men with subfertility issues. However, the magnitude of benefit appears modest, and not all studies have found significant improvements in fertility outcomes such as pregnancy rates. Still, the biological plausibility is strong due to folic acid's critical role in nucleotide metabolism and methylation processes necessary for spermatogenesis. There is no substantial traditional use of folic acid for male reproductive health, as this knowledge comes from more recent scientific investigations. Thus, while folic acid is not a guaranteed or primary treatment for male infertility, there is moderate scientific evidence supporting its role in supporting male reproductive health, mainly in men with suboptimal folate levels or fertility challenges.
Other ingredients that support Male Reproductive System
AbutaAlchornea
Allium tuberosum
amino acids
Angelica
animal protein
anise
anti-aromatase
antler
ashwagandha
aspartic acid
avocado
ba ji tian
barrenwort
bee products
Beef liver
beta-sitosterol
black galingale
black ginger
black seed
Borassus aethiopum
boron
Brazil nut
broccoli
Bulbine natalensis
Butea monosperma
Butea superba
Caesalpinia crista
caterpillar mushroom
catuaba
Chinese fleeceflower
Chinese mountain ant
Chinese pond turtle
Chlorophytum
cistanche
Clerodendrum phlomidis
Cnidium
cordyceps
cowage seed
Crinum latifolium
cruciferous
Cucurbita
Curculigo orchioides
Cyanotis arachnoides
Cyanotis vaga
Cynomorium
d-alpha tocopherol
D-Aspartic Acid
damiana
date
deer velvet
DHEA
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dodder
egg
elk antler
equol (proprietary)
Euryale seed
Eurycoma Longifolia
eurycomanone
Fadogia agrestis
fatty acids
fenugreek
fish
fo-ti
folate
folic acid
furostanols
garden cress
ginseng
Ginsenosides
gokhru
herbal blend (proprietary)
horny goat weed
Hygrophila
icariin
Indian sarsparilla
Jatropha macrantha
Kigelia africana
Kokilaksha
L-arginine
L-citrulline
Leptadenia
lingzhi
lipids
Loranthus
lycopene
maca
macaenes
macamides
magnesium
maral root
Massularia acuminata
Melatonin
Montanoa tomentosa
Muira puama
Nettle
Nigella seed
Nymphaea caerulea
Orchis latifolia
Osthole
parsley
Pedalium
pomegranate
protein
Protodioscin
pumpkin
pygeum
Rehmannia
rehmannia glutinosa
Rhaponticum
royal jelly
Safed musli
saffron
saw palmetto
selenium
Selenocysteine
Selenomethionine
Semecarpus anacardium
sesame
Shataverins
Shilajit
smilax
suma
Tiger Nut
Tongkat ali
trace minerals
Tribuloside
tribulus
Tribulus Terrestris
Trichilia catigua
velvet bean
vitamin B
vitamin D
vitamin E
Walnut
wheat germ
Withanolides
Yohimbe
Yohimbine
Zinc
Other body systems supported by folic acid
BloodBrain
Female Reproductive System
Heart
Immune System
Male Reproductive System
Nerves
Ovaries
Reproductive System
Uterus