Evidence supporting the use of: Human Chorionic Gonadotropin
For the body system: Male Reproductive System
Synopsis
Source of validity: Scientific
Rating (out of 5): 5
Human Chorionic Gonadotropin (hCG) is scientifically validated for use in supporting the male reproductive system, particularly in the management of hypogonadism and infertility. hCG is a glycoprotein hormone that mimics the action of luteinizing hormone (LH), stimulating the Leydig cells of the testes to produce testosterone. This mechanism is crucial in males with secondary hypogonadism—where the pituitary fails to signal the testes to produce testosterone—allowing for maintenance or restoration of endogenous testosterone levels without causing testicular atrophy. Clinical studies have shown that hCG therapy can increase intratesticular testosterone, preserve spermatogenesis, and support fertility in men, especially those undergoing testosterone replacement therapy (TRT) who wish to maintain fertility.
hCG is commonly used in conjunction with other agents like selective estrogen receptor modulators (SERMs) or FSH analogs for male infertility, particularly in cases of hypogonadotropic hypogonadism. Double-blind, placebo-controlled trials, as well as extensive clinical experience, support its efficacy and safety in these settings. The use of hCG in bodybuilding or as a weight-loss aid, however, lacks scientific support. In summary, hCG has a well-established, scientifically validated role in supporting the male reproductive system, particularly in fertility management and the treatment of certain types of hypogonadism.
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Other body systems supported by Human Chorionic Gonadotropin
Female Reproductive SystemMale Reproductive System
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