Evidence supporting the use of: L-citrulline
For the body system: Male Reproductive System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-citrulline is a non-essential amino acid that plays a role in the urea cycle and nitric oxide (NO) production. Its use to support the male reproductive system, particularly male sexual health and erectile function, is based on its ability to increase arginine levels and subsequently boost nitric oxide synthesis. Nitric oxide is a critical mediator of vasodilation, which is essential for achieving and maintaining erections. Several small clinical studies and trials have investigated L-citrulline supplementation in men with mild erectile dysfunction (ED). For example, a 2011 pilot study published in "Urology" found that L-citrulline supplementation improved erection hardness in men with mild ED compared to placebo. However, the sample sizes in these studies are generally small, and the improvements, while statistically significant, are often modest.

L-citrulline is not traditionally used in herbal or folk medicine specifically for male reproductive health, and its application is grounded in contemporary understanding of biochemistry and vascular function. While there is a plausible scientific mechanism and some supporting evidence for its role in enhancing blood flow and erectile function, more robust clinical trials are needed to establish its efficacy and optimal dosing. Overall, the scientific validation for L-citrulline’s use in supporting male reproductive function is moderate, meriting a score of 3 out of 5.

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