Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Selenomethionine is a major dietary form of selenium, an essential trace mineral. Scientific evidence supports selenium’s role in male reproductive health, primarily due to its function as an antioxidant and its involvement in the activity of selenoproteins, which are crucial for spermatogenesis and testosterone biosynthesis. Several studies have demonstrated that selenium supplementation, including in the form of selenomethionine, can improve sperm motility, morphology, and overall semen quality, particularly in men with low baseline selenium status or infertility. For example, a number of randomized controlled trials and meta-analyses suggest that selenium, often in combination with other antioxidants, may enhance sperm parameters and may modestly improve pregnancy rates in couples facing male infertility.

Furthermore, selenium is a component of the enzyme glutathione peroxidase, which protects sperm from oxidative damage, a key factor in male infertility. Deficiencies in selenium can lead to impaired sperm motility and structural abnormalities. However, while the evidence is promising, it is not uniformly strong, with some studies showing no benefit in men with adequate selenium levels, and concerns about toxicity at high doses. Thus, while there is scientific backing for selenium’s (and selenomethionine’s) role in supporting the male reproductive system, the evidence is moderate and context-dependent.

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