Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Testosterone precursors, such as dehydroepiandrosterone (DHEA) and androstenedione, are substances that the body can convert into testosterone, the primary male sex hormone. These precursors have been studied for their potential to support the male reproductive system, particularly in cases of low testosterone (hypogonadism) or age-related testosterone decline. There is scientific evidence that supplementation with certain testosterone precursors can increase testosterone levels modestly in some individuals, although the response is variable and depends on factors such as age, baseline hormone levels, and dosage. Clinical trials with DHEA, for example, have shown small increases in serum testosterone in older men and those with adrenal insufficiency. However, the efficacy of these supplements in improving reproductive function, fertility, or sexual health outcomes is less clear, and results are mixed. Some studies report improvements in libido or erectile function, while others find no significant benefit. Furthermore, safety concerns exist, as increased testosterone from precursors may raise the risk of side effects, including cardiovascular issues and prostate enlargement. Regulatory agencies such as the FDA do not endorse over-the-counter testosterone precursor supplements for these uses due to insufficient evidence and potential risks. In summary, while there is a scientific basis for the use of testosterone precursors to support the male reproductive system, the overall evidence is moderate and not universally conclusive.

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