Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B9, also known as folate or folic acid, has scientific evidence supporting its role in male reproductive health, particularly regarding sperm quality and fertility. Several studies have shown that adequate folate levels are associated with improved sperm concentration, motility, and reduced sperm DNA damage. Folate is essential for DNA synthesis and repair, making it important in the rapidly dividing cells of spermatogenesis. Some clinical trials and observational studies have found that men with low folate intake or status tend to have a higher proportion of sperm with chromosomal abnormalities and DNA fragmentation, which can negatively impact fertility and increase the risk of birth defects. Supplementation with folic acid, often in combination with other antioxidants (such as zinc), has been investigated for treating male infertility, with mixed but generally positive results in terms of sperm parameters.

However, the quality of evidence is moderate; while biological plausibility and supportive data exist, not all studies show consistent improvements in live birth rates or pregnancy outcomes with folate supplementation in men. Most research uses surrogate endpoints like sperm count and DNA integrity rather than direct measures of fertility. Overall, folate is scientifically validated to support aspects of the male reproductive system, particularly sperm health, but its impact on actual fertility outcomes requires further research.

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